Figure 3
Differential transcriptional response of Irf1−/− mutants to AOM/DSS. (A) Global comparison of genes differentially expressed in B6 control vs. AOM/DSS treated B6, and control Irf1−/− vs. AOM/DSS-treated Irf1−/−, and calculated as fold change (log2). Genes differentially expressed specifically in Irf1−/− (orange dots), specifically in B6 (purple) or common to both (green) are shown. (B) Heat map of genes significantly upregulated (FC ≥1.5, FDR ≤10−2) in both Irf1−/− and B6 responses, or in Irf1−/− only, or in B6 only. Enriched GO terms are shown to the side according to Benjamini-adjusted p-value significance. GSEA analysis of human IBD (C) and CRC (D) signatures as described in Materials and Methods.
