Figure 6
Association of Human IRF1 with Ulcerative Colitis and Colorectal Cancer. Overlap between mouse RNAseq datasets for genes upregulated in response to AOM/DSS (at D26) for each genotype (B6, Irf1−/−; FC >1.5, FDR < 0.01) and genes upregulated in microarray datasets from active Human UC (A) or UC in remission (B) (FC >2, FDR <0.5). Fisher’s exact test was used to compute the significance of these overlaps compared to a randomly generated set of genes, with p-values indicated. (C) Analysis of TCGA database for IRF1 mRNA expression in human CRC samples obtained at different stages of the disease. (D) Kaplan-Meier survival curve of Stage T3 and T4 patients with high or low IRF1 gene expression level. Patients were classified by their relative expression of IRF1 compared to the mean IRF1 expression level of all Stage T3 and T4 CRC patients.
