Figure 3
From: Using mechanistic models for the clinical interpretation of complex genomic variation
Signaling circuits analyzed in the diabetes case study. Nodes in orange contain genes whose LoF causes an upregulation of the circuit and nodes in blue contain genes whose inactivation causes circuit downregulation. (A) Rap1 signaling pathway:PRKCI PARD6A PARD3, (B) Chemokynes pathway:PARD3-PRKCZ-TIAM1 and (C) TNF signaling pathway:CREB3 circuits.
