Figure 4
From: Using mechanistic models for the clinical interpretation of complex genomic variation
Effect of genes with LoF mutations using the pancreatic islet tissue as used defined tissue, and comparing the resulting pathway activity after the simulations with those displayed by both the normal and the type 2 diabetes tissues. (A) Rap1 signaling pathway:PRKCI PARD6A PARD3, (B) Chemokynes pathway:PARD3-PRKCZ-TIAM1 and (C) TNF signaling pathway:CREB3 circuits.
