Table 3 Correlations between DAMP concentrations and clinical characteristics in patients with ACO.

From: Differential DAMP release was observed in the sputum of COPD, asthma and asthma-COPD overlap (ACO) patients

Characteristic

HSP70

Gal-3

S100A8

LL-37

HMGB1

MRC score

−0.101*

−0.185

0.219

0.364

0.311*

FEV1 (L)

−0.049

0.115

−0.522**

−0.273*

−0.464**

FEV1 pred (%)

−0.035

0.133

−0.543**

−0.383**

−0.509**

FEV1/FVC (%)

−0.057

0.124

−0.240

−0.266

−0.366*

Sputum cell counts

TCC (106/ml)

0.031

−0.002

0.314*

0.126

0.377*

Macrophages (%)

0.064

−0.043

−0.327*

−0.337*

−0.394**

Neutrophils (%)

0.104*

0.102

0.338*

−0.408**

0.432**

Lymphocytes (%)

0.143

−0.112

0.098

0.066

0.335*

  1. Study participants (N = 68). Data are Spearman rank correlation coefficients between variables. MRC: Medical Research Council Scale; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; *p < 0.05; **p < 0.01.
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