Table 4 Multivariate analysis was adjusted for sex, age, BMI, smoking pack-years, ICS use and all the significant variables in the univariate analysis. TCC, total cell count.

From: Differential DAMP release was observed in the sputum of COPD, asthma and asthma-COPD overlap (ACO) patients

  

B

t

P value

HSP70

Percentage of neutrophils

0.008

2.938

0.004

Gal-3

FEV1/FVC%

3.171

3.515

0.001

S100A8

Sputum neutrophils counts

100.598

5.368

≤0.001

 

FEV1

−182.232

−4.336

≤0.001

LL-37

FEV1%pred

−0.597

−6.928

≤0.001

 

Percentage of neutrophils

−1.805

−3.884

≤0.001

HMGB1

FEV1%pred

−0.146

−9.265

≤0.001

 

TCC

1.100

6.263

≤0.001

  1. Dependent variable: HSP70. R2:0.063, adjusted R2 :0.068, p = 0.004. Dependent variable: gal-3; R2:0.124, adjusted R2 :0.116, p = 0.013. Dependent variable: S100A8. R2:0.373, adjusted R2 :0.346, p ≤ 0.001. Dependent variable: LL-37. R2:0.215, adjusted R2 :0.204, p = 0.025. Dependent variable: HMGB1. R2:0.689, adjusted R2 :0.568, p ≤ 0.001.
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