Figure 5

HLA-DRB1*0401 mice survive longer than *0402 mice and generate differential immune response to superantigen. (A) In vitro response to Staphylococcus enterotoxin B (SEB) and α-CD3 of splenocytes harvested from naïve mice at indicated time points, *P = 0.06, **P = 0.03 and (B) cytokine response from the culture supernatants from 4A. ^#P = 0.01, **P = 0.03. Data represents Mean ± SEM (N = 3 mice/strain). *0401 vs *0402, IFN-γ, 2-3mo- SEB, *P < 0.001, CD3, P < 0.07; IL-13, *0401 vs *0402, SEB and CD3, for 2-3mo and 12-14mo P < 0.001. (C) Kaplan Meier plot for *0401 (N = 23), *0402 (N = 21) and AEo (N = 10) naïve mice, *0401 vs *0402, P < 0.001.