Table 2 Bladder stress–associated receptors and neurotrophin expression in patients with IC/BPS and control patients.

From: Dysregulation of bladder corticotropin-releasing hormone receptor in the pathogenesis of human interstitial cystitis/bladder pain syndrome

 

(A)

Controls

(N = 24)

(B)

NHIC

(N = 51)

(C)

HIC

(N = 23)

Total

IC/BPS

(N = 74)

P value*

P value**

Post hoc

CRHR1

1.14 ± 0.52

1.34 ± 1.72

2.90 ± 1.43

1.82 ± 1.78

0.004

<0.001

A vs B = 0.89

A vs C < 0.001

B vs C < 0.001

CRHR2

0.55 ± 0.45

0.31 ± 0.48

0.21 ± 0.32

0.28 ± 0.43

0.01

0.03

A vs B = 0.10

A vs C = 0.04

B vs C = 0.67

NGF

0.83 ± 0.61

0.61 ± 0.42

1.32 ± 0.79

0.83 ± 0.65

0.99

<0.001

A vs B = 0.29

A vs C = 0.02

B vs C < 0.001

E-cadherin

0.60 ± 0.26

0.31 ± 0.30

0.19 ± 0.20

0.27 ± 0.28

<0.001

<0.001

A vs B < 0.001

A vs C < 0.001

B vs C = 0.20

  1. HIC: IC/BPS patients with Hunner’s lesion; NHIC: IC/BPS patients without Hunner’s lesion; CRHR: corticotropin-releasing hormone receptor; NGF: nerve growth factor.
  2. The proteins expression levels were given by the relative intensity compared with GAPDH.
  3. *P-value for Independent t-test comparing controls and total IC/BPS patients.
  4. **P-value for ANOVA of control, non-ulcer, and ulcer IC/BPS patients.
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