Table 2 Top 20 up- and down-regulated proteins of significant difference in KPC-KP cells exposed to LVO.

From: Lavender essential oil induces oxidative stress which modifies the bacterial membrane permeability of carbapenemase producing Klebsiella pneumoniae

No	Proteins	Gene name	Uniprot accession no.	General function	Cellular component	Fold change
Upregulated proteins
1	NAD(P)H dehydrogenase (quinone)	wrbA	B5XXP0	Stress response	Membrane	5.15458
2	Beta-lactamase SHV-11	blaSHV-11	P37323	Stress response	Cytoplasm	4.62696
3	Ribosome-recycling factor	frr	B5Y1J9	Protein biosynthesis	Cytoplasm	4.54865
4	Phosphopentomutase	deoB	B5Y275	Metabolic intermediate biosynthesis	Cytoplasm	4.05602
5	Diacetyl reductase [(S)-acetoin forming]	budC	Q48436	Acetoin metabolism	Cytoplasm	4.01896
6	Cell division protein ZapB	zapB	A6TFR0	Cell division	Membrane	3.66352
7	Uridine phosphorylase	udp	P52671	Nucleotide metabolism	Cytoplasm	3.41065
8	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	dapD	B5Y1K5	Cell wall biosyntheiss	Cytoplasm	3.27497
9	Elongation factor Ts	tsf	A6T4X2	Protein biosynthesis	Cytoplasm	3.19873
10	Methionine–tRNA ligase	metG	A6TBK7	Protein biosynthesis	Cytoplasm	2.92754
11	Carbapenem-hydrolyzing beta-lactamase KPC	bla	Q9F663	Stress response	Cytoplasm	2.90361
12	Adenylate kinase	adk	A6T5N7	Nucleotide metabolism	Cytoplasm	2.87125
13	DNA protection during starvation protein	dps	A6T6Q6	DNA processing	Cytoplasm	2.87
14	Glucose-6-phosphate isomerase	pgi	A6TGT4	Energy synthesis	Cytoplasm	2.78288
15	Xanthine phosphoribosyltransferase	gpt	A6T532	Nucleotide metabolism	Membrane	2.72207
16	Autonomous glycyl radical cofactor	grcA	A6TCJ1	Stress response	Cytoplasm	2.71508
17	Purine nucleoside phosphorylase DeoD-type	deoD	B5Y274	Nucleotide metabolism	Membrane	2.54311
18	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	gpmA	B5XZB2	Energy synthesis	Cytoplasm	2.43127
19	50S ribosomal protein L7/L12	rplL	A6TGN9	Protein biosynthesis	Ribosomal protein	2.32274
20	3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	fabA	A6T748	Fatty acid biosynthesis	Cytoplasm	2.26672
Downregulated proteins
21	NADH-quinone oxidoreductase subunit B	nuoB	A6TBX3	Transporter protein	Membrane	−5.59153
22	Outer membrane protein A	ompA	P24017	Transporter protein	Membrane	−5.24924
23	Mannitol-1-phosphate 5-dehydrogenase	mtlD	A6TFJ4	Manitol metabolism	Cytoplasm	−4.12857
24	ATP synthase subunit c	atpE	B5XZL9	Energy synthesis	Membrane	−3.95817
25	60 kDa chaperonin	groL	A6TH53	Stress response	Cytoplasm	−3.92018
26	ATP synthase subunit b	atpF	B5XZM0	Energy synthesis	Membrane	−3.89086
27	NADH-quinone oxidoreductase subunit A	nuoA	A6TBX4	Transporter protein	Membrane	−3.74012
28	D-erythrose-4-phosphate dehydrogenase	epd	A6TDT2	Cofactor biosynthesis	Cytoplasm	−3.51524
29	Exodeoxyribonuclease 7 small subunit	xseB	B5Y0W9	DNA processing	Cytoplasm	−3.47431
30	ATP phosphoribosyltransferase	hisG	B5XPE8	Protein biosynthesis	Cytoplasm	−3.3997
31	ATP synthase gamma chain	atpG	A6TG37	Energy synthesis	Membrane	−3.39661
32	ATP synthase subunit beta	atpD	A6TG36	Energy synthesis	Membrane	−3.32617
33	DNA-directed RNA polymerase subunit beta	rpoB	A6TGP0	DNA processing	Cytoplasm	−3.20933
34	DNA-directed RNA polymerase subunit alpha	rpoA	A6TEU8	DNA processing	Cytoplasm	−3.19363
35	Chaperone protein DnaJ	dnaJ	A6T4F5	Stress response	Cytoplasm	−3.15398
36	50S ribosomal protein L35	rpmI	B5XQC8	Protein biosynthesis	Ribosomal protein	−3.12775
37	Leucine-responsive regulatory protein	lrp	P37424	DNA processing	Cytoplasm	−3.05971
38	Outer membrane protein C	ompC	Q48473	Transporter protein	Membrane	−3.03548
39	ATP synthase epsilon chain	atpC	A6TG35	Energy synthesis	Membrane	−3.03454
40	Lipoyl synthase	lipA	B5XZS6	Protein biosynthesis	Cytoplasm	−3.02594

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Table 2 Top 20 up- and down-regulated proteins of significant difference in KPC-KP cells exposed to LVO.

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