Table 4 Summary of existing paediatric reference intervals for FT4 using direct sampling approach.

From: Routine free thyroxine reference intervals are suboptimal for monitoring children on thyroxine replacement therapy and target intervals need to be assay-specific

 

Published paediatric reference intervals

This study (11 months − 18 years)

Source

Age

Reference intervals

Beckman

Adeli et al.14

20 days–<3 years

9.5–17.8

9.8–17.9

  

3–19 years

7.8–13.6

Siemens

Kapelari et al.23

1–12 months

9.2–25.3

12.8–22.3

  

1–5 years

10.5–22.4

  

6–10 years

10.6–20.9

  

11–14 years

10.4–21.4

  

15–18 years

10.6–22.6

Roche

Taylor et al.24

7 years

12.7–19.3

11.3–24.1

  

15 years

11.9–20.3

Abbott

Adeli et al.14

30 days–<1 year

11.4–21.9

14.9–26.2

  

1–<19 years

11.4–17.6

Vitros

Adeli et al.14

2 weeks–<5 years

11.4–29.2

11.7–19.7

  

5–<19 years

9.7–17.1