Figure 1
Baseline average spontaneous activity (horizontal and vertical) of HLA-DR3.DQ8 Tg mice during the day (diurnal) and night (nocturnal). (A) Average daily counts of spontaneous diurnal and nocturnal horizontal activity of healthy HLA-DR3.DQ8 Tg mice. Measurements were obtained for 24 hours up to day 5. (B) Average daily counts of 5 days spontaneous diurnal and nocturnal horizontal activity of healthy HLA-DR3.DQ8 Tg mice. (C) Average daily counts of spontaneous diurnal and nocturnal activity of healthy HLA-DR3.DQ8 Tg mice. Measurements were obtained for 24 hours up to day 5. (D) Average of 5 day counts of spontaneous diurnal and nocturnal activity of healthy HLA-DR3.DQ8 Tg mice. (E) Comparison of the average daily counts of spontaneous horizontal and vertical nocturnal activity of healthy HLA-DR3.DQ8 Tg mice for 24 hours up to day 5. (F) Comparison of the average of 5 day counts of spontaneous horizontal and vertical nocturnal activity of healthy HLA-DR3.DQ8 Tg mice. For all panels, the data represent one experiment out of three performed. (n ≥ 7 mice per group). The p values in A, C, E and F were calculated using an unpaired t test with two step-up methods of Benjamini, Krieger and Yekutieli. The p-value in B was calculated using an unpaired t test with Welch’s correction, and that in D was calculated using an unpaired t test using the Kolmogorov-Smirnov test. *indicates p ≤ 0.05, ** indicates p < 0.005 when comparing diurnal vs. nocturnal baseline activity.
