Table 2 Top 10 largest percent change in global efficiency upon removal of a node in HC and AD.

Node	RSN	HC Baseline	HC One-year	AD Baseline	AD One-year	AD − HC Baseline	AD − HC One-year
85	SM	−1.04	−1.16	−0.85	−0.83	0.18	0.32
81	SM	−1.00	−1.08	−0.91	−0.86	0.09	0.21
51	DMN	−1.06	−0.96	−0.88	−0.86	0.19	0.09
64	DMN	−0.96	−1.06	−0.94	−0.85	0.03	0.2
137	EC	−0.97	−1.02	−0.83	−0.82	0.14	0.2
166	EC	−0.98	−0.88	−0.82	−0.78	0.16	0.11
59	DMN	−0.98	−0.98	−0.79	−0.81	0.18	0.17
143	EC	−0.97	−0.94	−0.85	−0.82	0.12	0.12
70	Cerebellum	−0.95	−0.84	−0.77	−0.77	0.18	0.07
71	Cerebellum	−0.95	−0.85	−0.81	−0.83	0.13	0.02

The final two columns display the difference in percent loss between AD and HC at that node at baseline and at one−year. All of the differences between AD and HC are positive, indicating that HC saw a larger reduction in global efficiency.

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