Table 8 Top 10 largest percent change in CPL upon removal of a node in HC and AD using the graphical lasso.

Node	RSN	HC Baseline	HC One-year	AD Baseline	AD One-year	AD − HC Baseline	AD − HC One-year
*128	Aud	−0.01	−0.2	−0.09	−0.07	−0.08	0.13
*107	Aud	−0.02	−0.18	−0.06	−0.08	−0.04	0.1
*114	Aud	0	−0.09	−0.17	−0.08	−0.17	0.01
*123	Aud	−0.01	−0.09	−0.17	−0.08	−0.16	0.01
207	FPR	0.06	0.17	0.07	0.04	0.01	−0.13
110	Aud	0	0.15	0.03	0	0.03	−0.14
252	Unk	0.02	0.12	0.07	0.07	0.05	−0.06
149	EC	0.03	0.12	0.09	0.03	0.06	−0.09
169	EC	0.02	0.12	0.03	0.03	0.01	−0.09
164	EC	0.04	0.07	0.12	0.02	0.08	−0.04

Positive (negative) values indicate that removal of this node increased (decreased) the CPL. The final two columns display the difference in percent change between AD and HC at that node at baseline and at one-year. A *before a node indicates that it was not a hub in any of the cohorts/visits, as identified by the graphical lasso.

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