Figure 4 | Scientific Reports

Figure 4

From: Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson’s disease with dementia

Figure 4

Kinetics on inhibition and dissociation of Aβ1–42 oligomer formation by D-520: (A–C) ThT fluorescence of Aβ1–42 (10 μM) with or without incubation with either D-520 (20 μM, Panel: A) or D-520 (10 μM, Panel: B) or D-520 (1 or, 0.1 or 0.01 μM, Panel: C) for 24 h. (D) ThT fluorescence of Aβ1–42 fibrils (10 μM) with or without incubation with D-520 (20 μM) for 24 h. The ThT fluorescence of Aβ1–42 at 0 h was considered as 100%. One-way ANOVA followed by Tukey’s multiple comparison post hoc test, ****P < 0.0001 comparing abeta to abeta + D520 (Panel A-C) and ****P < 0.0001 comparing abeta fibrils to abeta fibril + D520 (Panel D).

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