Figure 1

Intrahepatic cholangiocarcinoma (ICC) in a 62–year-old male. (see Supplementary Video S1). (a) Conventional ultrasound shows a hypoechoic lesion with a size of 4.2 cm × 3.5 cm in the left lobe of the liver (cursors); (b) Color Doppler sonography indicates a relatively sparse blood supply; (c) During the arterial phase (23 s), the lesion exhibits heterogeneous hyperenhancement; (d) During the portal venous phase (81 s), the lesion exhibits hypoenhancement of its interior with hyperenhancement in the peripheral region, resulting in the formation of a hyperenhanced rim; (e) During the late phase (186 s), the lesion exhibits hypoenhancement; (f) Micrograph (original magnification, ×100; hematoxylin and eosin stain) reveals that the periphery of the tumor is irregular and intermingled with the adjacent normal hepatic tissue. The lesion shows an infiltrative characteristic. (g) The parametric curves reveal perfusion of the region of interest in the interior (light green, Peak = 50.2, Sharpness = 0.074 1/s) and periphery (dark green, Peak = 53.1, Sharpness = 0.024 1/s) of the lesion from 10 s to 180 s.