Table 2 Associations between the BMO area and various clinical and ocular parameters among the 53 subjects (26 mm ≤ axial length <27 mm).

From: Bruch’s membrane opening enlargement and its implication on the myopic optic nerve head

Variables

Univariable

Adjusted for age, sex and axial length

Coefficient (95% CI)

P-value*

Coefficient (95% CI)

P-value*

Age (years)

−0.004 (−0.090, 0.083)

0.933

Female gender

−0.007 (−0.043, 0.072)

0.570

Axial length (mm)

0.252 (−0.583, 1.088)

0.547

Central corneal thickness (μm)

−0.013 (−0.018, 0.002)

0.112

−0.010 (−0.018, 0.003)

0.135

Corneal curvature (D)

−0.037 (−0.267, 0.194)

0.749

−0.041 (−0.274, 0.192)

0.725

IOP (mmHg)

0.049 (−0.038, 0.136)

0.262

0.058 (−0.033, 0.148)

0.208

PPA+BM width (μm)

−0.000081 (−0.001, 0.001)

0.896

−0.000085 (−0.001, 0.001)

0.892

PPA−BM (γ zone PPA) width (μm)

0.002 (0.001, 0.002)

<0.001

0.002 (0.001, 0.002)

<0.001

LC thickness (μm)

−0.000283 (−0.006, 0.005)

0.922

−0.001 (−0.007, 0.005)

0.835

Anterior laminar depth (μm)

0.002 (0.001, 0.004)

0.031

0.003 (0.001, 0.005)

0.016

FoBMO angle (°)

0.039 (−0.026, 0.104)

0.232

0.037 (−0.030, 0.104)

0.274

LC defect

0.723 (0.314, 1.132)

0.001

0.720 (0.307, 1.132)

0.001

BMO-MRW (μm)

    Global

−0.008 (−0.013, −0.004)

<0.001

−0.008 (−0.013, −0.004)

<0.001

    Temporal-superior

−0.005 (−0.009, −0.001)

0.019

−0.005 (−0.009, −0.001)

0.019

    Temporal

−0.004 (−0.011, 0.002)

0.172

−0.004 (−0.011, 0.002)

0.176

    Temporal-inferior

−0.007 (−0.010, −0.003)

<0.001

−0.007 (−0.010, −0.003)

<0.001

    Nasal-inferior

−0.008 (−0.012, −0.005)

<0.001

−0.008 (−0.012, −0.005)

<0.001

    Nasal

−0.006 (−0.009, −0.003)

<0.001

−0.006 (−0.009, −0.003)

<0.001

    Nasal-superior

−0.003 (−0.006, 0.001)

0.025

−0.003 (−0.006, −0.0004)

0.024

Peripapillary choroidal thickness (μm)

    Global

−0.005 (−0.010, −0.0003)

0.034

−0.005 (−0.010, −0.0002)

0.040

    Temporal-superior

−0.003 (−0.007, 0.001)

0.185

−0.003 (−0.006, 0.001)

0.208

    Temporal

−0.004 (−0.008, 0.000)

0.077

−0.004 (−0.008, 0.001)

0.093

    Temporal-inferior

−0.006 (−0.011, −0.001)

0.016

−0.006 (−0.011. −0.001)

0.017

    Nasal-inferior

−0.006 (−0.011, −0.002)

0.010

−0.006 (−0.011, −0.001)

0.013

    Nasal

−0.005 (−0.009, −0.0003)

0.034

−0.005 (−0.009, −0.0002)

0.038

    Nasal-superior

−0.003 (−0.007, 0.001)

0.134

−0.003 (−0.007, 0.001)

0.141

Subfoveal choroidal thickness (μm)

−0.002 (−0.004, 0.001)

0.169

−0.002 (−0.004, 0.001)

0.204

  1. CI = confidence interval; D = diopter; IOP = intraocular pressure; BMO = Bruch’s membrane opening; PPA+BM = β-parapapillary atrophy with Bruch’s membrane; PPA−BM = β-parapapillary atrophy without Bruch’s membrane; LC = lamina cribrosa; FoBMO angle = angle of fovea-to-BMO-center axis relative to the horizontal axis of the image frame; MRW = minimum rim width.
  2. Factors with statistical significance are shown in boldface.
  3. *P values were adjusted with Benjamini-Hochberg procedure.