Figure 3
From: The bradykinin system in stress and anxiety in humans and mice
Expression levels of KLK-related genes after chronic social defeat stress in mice. Agtr2, Bdkrb1, Klk1, Klk12, Klkb1, Kng1 and Kng2 were included in the analysis but their expression levels were below the detection level in both brain regions. F12, Bdkrb2 and Aplnr expression levels were below the detection level in the mPFC. LogCPM = normalised expression level in log Counts Per Million from RNA-sequencing. P-values (from moderated t-test for differential expression) are corrected for multiple testing with Benjamini-Hochberg method. Box plots show minimum, 1st quartile, median, 3rd quartile, and maximum expression value for each group. Data outliers (values > 1.5 interquartiles from the IQR range) are depicted by a dot. vHPC = ventral hippocampus, mPFC = medial prefrontal cortex, B6 = C57BL/6NCrl, D2 = DBA/2NCrl. N of mice: mPFC (B6: controls 6, resilient 6, susceptible 6; D2: controls 6, susceptible 8) and vHPC (B6: controls 6, resilient 8, susceptible 3; D2: controls 6, susceptible 5). *p < 0.05, **p < 0.01, ***p < 0.001 compared to the same-strain control group.
