Figure 4
From: The bradykinin system in stress and anxiety in humans and mice
The effect of bradykinin receptor antagonists on anxiety-like behaviour. We injected DBA/2NCrl mice subcutaneously with B1 receptor non-peptide receptor antagonist ELN-441958 or B2 receptor non-peptide antagonists bradyzide or WIN 64338 and carried out behavioural testing 30 min later in the open field test (N = 8–12 per group) (a,b), in the novelty suppressed feeding test (N = 8–10 per group) (c) and in the elevated plus maze test (N = 7–9 per group) (d,e). Bars represent the mean ± SEM. *p < 0.05, **p < 0.001 compared to the vehicle (PBS/0.05% DMSO) group.
