Table 1 SNPs showing evidence for association at p < 0.05 level in allele or genotype-based test.

Gene	SNP	Alleles [A1/A2]	Group	Allele frequencies		Allelic LRT p-value	Genotype frequences			Genotypic LRT p-value
Gene	SNP	Alleles [A1/A2]	Group	A1	A2	Allelic LRT p-value	A1/A1	A1/A2	A2/A2	Genotypic LRT p-value
BDKRB1	rs2069613	C/T	Cases	0.107	0.893	0.0220	0.009	0.195	0.796	0.0753
			Controls	0.143	0.857		0.020	0.246	0.734
	rs4905475	C/G	Cases	0.136	0.864	0.0006	0.016	0.241	0.743	0.0007
			Controls	0.083	0.917		0.014	0.138	0.848
	rs11622768	C/T	Cases	0.864	0.136	0.0003	0.744	0.240	0.016	0.0006
			Controls	0.917	0.083		0.848	0.138	0.014
	rs10147171	C/T	Cases	0.137	0.863	0.0002	0.016	0.242	0.742	0.0001
			Controls	0.084	0.916		0.014	0.140	0.846
	rs10137303	A/G	Cases	0.863	0.137	0.0008	0.742	0.242	0.016	0.0009
			Controls	0.918	0.082		0.850	0.136	0.014
	rs11628515	A/T	Cases	0.136	0.864	0.0005	0.016	0.241	0.743	0.0006
			Controls	0.083	0.917		0.014	0.138	0.848
	rs4349080	A/G	Cases	0.197	0.803	0.0139	0.054	0.287	0.659	0.0332
			Controls	0.249	0.751		0.069	0.361	0.571
	rs945034	C/T	Cases	0.540	0.460	0.0353	0.299	0.481	0.220	0.0900
			Controls	0.590	0.410		0.345	0.491	0.165
BDKRB2	rs4900311	A/G	Cases	0.454	0.546	0.0096	0.208	0.492	0.300	0.0323
			Controls	0.517	0.483		0.263	0.509	0.229
	rs1799722	C/T	Cases	0.595	0.405	0.7747	0.328	0.533	0.139	0.0296
			Controls	0.588	0.412		0.364	0.448	0.188
	rs2069575	A/G	Cases	0.117	0.883	0.0105	0.019	0.196	0.785	0.0239
			Controls	0.160	0.840		0.023	0.274	0.703
	rs5225	C/T	Cases	0.139	0.861	0.0022	0.016	0.246	0.738	0.0041
			Controls	0.092	0.908		0.014	0.156	0.830
	rs2069596	A/G	Cases	0.151	0.849	0.0080	0.019	0.263	0.717	0.0112
			Controls	0.108	0.892		0.019	0.179	0.803
KNG1	rs13315296	C/T	Cases	0.519	0.481	0.0404	0.286	0.465	0.248	0.0917
KNG1			Controls	0.468	0.532		0.223	0.491	0.287

P-values surviving gene-wide Bonferroni correction for multiple testing are shown in bold.

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