Figure 5 | Scientific Reports

Figure 5

From: Discordant gene responses to radiation in humans and mice and the role of hematopoietically humanized mice in the search for radiation biomarkers

Figure 5

Relative gene expression changes after radiation in human and mouse cells 24 hours after irradiation (similar response patterns). Genes were selected from microarray analyses for showing similar responses to radiation in both human and mouse blood. Values are mean fold change of n > 5 biological replicates, for four experimental groups Human (Human blood irradiated ex vivo, pink line and symbols), HuNSG (Humanized NSG mice whole body irradiation, human genes, purple line and symbols), C57BL/6 (mice after whole body irradiation, light blue line and symbols) and NSG (age-matched NSG non-engrafted mice after whole body irradiation, dark blue line and symbols). The grey line indicates the calibrator sample, which is the matched sham-irradiated sample for each experimental group.

Back to article page