Figure 1
From: Farnesoid X receptor and bile acids regulate vitamin A storage
FXR deficiency impairs hepatic retinoid storage. Whole body FXR-null mice and age-match wild-type control mice were analyzed for (A) H&E and oil red O staining, which revealed fat accumulation in livers of FXR-null mice as compared to control mice, while autofluorescence analysis revealed reduced vitamin A levels in livers of FXR-null mouse. (B) The body weight was not altered FXR-null mice, while the liver weight was increased in FXR-null mice. As expected, hepatic expression of Plin2, Fasn and Acc1 were increased in FXR-null mice vs wild-type mice. (C) hepatic retinyl palmitate and retinol levels were reduced in FXR-null mice, while plasma retinol levels were equal in both groups. Data are presented as Mean ± SEM and mRNA expression of genes is presented in 2−delta CT, which was normalized to 36B4.
