Figure 2
From: Farnesoid X receptor and bile acids regulate vitamin A storage
Hepatic and not intestinal FXR is essential for normal retinoid levels in the liver. (A) Hepatic retinyl palmitate and retinol were analyzed in intestinal specific FXR-null mice (iFXR-null) and wild-type littermates. Intestine-specific FXR-deficiency did not alter hepatic vitamin A levels. (B) Whole body FXR-null mice were transduced with ScAAV-produced FXRα2 or FXRα4 or GFP controls and after 4 weeks analyzed for hepatic retinyl palmitate and retinol levels. Both FXR-isoform enhanced hepatic retinoid levels, suggesting that hepatic FXR plays a crucial role in vitamin A storage and metabolism.
