Table 2 Physiological parameters of Nr3c1Pax8/LC1 mice after 4 days under low K+ diet. “nd” indicates not determined.

From: Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion

Parameters

K+-deficient diet

Controls

Nr3c1Pax8/LC1

n

6

6

Body weight (g)

22.90 ± 0.50

23.49 ± 0.78

Food intake (g)

3.19 ± 0.12

2.98 ± 0.18

Water intake (ml)

4.15 ± 0.36

7.84 ± 0.53*

Urine volume (ml)

1.98 ± 0.35

3.88 ± 0.30*

Urine/water ratio (ml)

0.41 ± 0.04

0.32 ± 0.05

Feces (g)

0.37 ± 0.04

0.35 ± 0.03

Urinary Na+ (mmol)

0.26 ± 0.03

0.17 ± 0.02

Urinary K+ (mmol)

0.02 ± 0.01

0.01 ± 0.01

Cumulative Na+ (mmol)

1.46 ± 0.13

0.95 ± 0.12**

Cumulative K+ (mmol)

0.18 ± 0.03

0.08 ± 0.02*

Urinary calcium (µmol/24 h)

6.61 ± 0.78

9.64 ± 1.51*

Urinary phosphate (mg/24 h)

1.63 ± 0.33

1.90 ± 0.32

Plasma Na+ (mmol)

154.2 ± 4.2

156.1 ± 2.2

Plasma K+ (mmol)

4.4 ± 0.2

5.9 ± 0.3***

Aldosterone (nM)

nd

nd

Plasma osmolality (mOsm/kgH2O)

292.67 ± 11.33

309.00 ± 5.29

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