Table 1 Baseline characteristics of the study participants according to alcohol consumption patterns over the follow-up period.
Never-drinkers (N = 353) | Chronic heavy drinkers (N = 420) | P-valueb | |
|---|---|---|---|
Age (y) | 53.3 ± 9.3 | 49.6 ± 8.2 | <0.0001 |
BMI (kg/m2) | 23.7 ± 3.0 | 24.3 ± 2.9 | 0.1454 |
SBP (mmHg) | 119.9 ± 15.8 | 123 ± 16.3 | <0.0001 |
DBP (mmHg) | 79.9 ± 10.7 | 83.5 ± 10.7 | <0.0001 |
AST (IU/L)a | 26.2 ± 17.1 | 33.9 ± 23.0 | <0.0001 |
ALT (IU/L)a | 26.8 ± 18.6 | 32.3 ± 21.0 | 0.0002 |
GTP (IU/L)a | 27.9 ± 19.7 | 84.3 ± 118.7 | <0.0001 |
Total cholesterol (mmol/L) | 5.1 ± 0.9 | 5.1 ± 1.0 | 0.5584 |
HDL-cholesterol (mmol/L) | 1.2 ± 0.3 | 1.3 ± 0.3 | <0.0001 |
Triglycerides (mmol/L)a | 1.6 ± 1.0 | 2.2 ± 1.8 | <0.0001 |
Fasting glucose (mmol/L) | 4.9 ± 0.5 | 5.1 ± 0.5 | <0.0001 |
1 h glucose (mmol/L) | 8.5 ± 2.5 | 9.1 ± 2.5 | <0.0001 |
2 h glucose (mmol/L) | 6.4 ± 1.9 | 6.7 ± 1.9 | 0.0051 |
Fasting insulin (μU/mL)a | 7.0 ± 5.7 | 6.6 ± 3.3 | 0.7919 |
1 h insulin (μU/mL)a | 29.4 ± 27.5 | 30.1 ± 30.3 | 0.3509 |
2 h insulin (μU/mL)a | 25.0 ± 23.7 | 22.8 ± 24.2 | 0.0826 |
HOMA-B (%)a | 113.7 ± 110 | 90.2 ± 51.5 | 0.0007 |
IGI60a | 9.3 ± 15.7 | 8.5 ± 15.8 | 0.0180 |
I/GAUC 60–120a | 3.7 ± 2.7 | 3.4 ± 3.0 | 0.0033 |
I/G120a | 3.8 ± 3.1 | 3.3 ± 2.9 | 0.0036 |
Composite ISIa | 13.1 ± 12.6 | 12.3 ± 9.8 | 0.8053 |
Disposition indexa | 75.7 ± 90.3 | 67.0 ± 90.0 | 0.0049 |
MET (Physical activity) | 10223.6 ± 6309.4 | 10916.9 ± 6582.8 | 0.0033 |
Smoking (ex/current) | 26.4%/38.6% | 28.1%/61.7% | <0.0001 |
Family history of diabetes | 9.4% | 12.6% | 0.1497 |