Table 1 Demographic characteristics of the 70 Allo-HSCT recipients and risk factors for TB occurrence.
70 Allo-HSCT recipients | Subjects with TB (n = 14) | Subjects without TB (n = 56) | P value | ||
|---|---|---|---|---|---|
Demographic characteristics | 27.5 | 9–60 | 29 | 9–65 | |
Age | 0.988 | ||||
Sex | 0.923 | ||||
Male | 9 | 64.29% | 36 | 64.29% | |
Female | 5 | 35.71% | 20 | 35.71% | |
Underlying disease | 0.983 | ||||
Acute lymphoblastic leukaemia | 3 | 21.43% | 24 | 42.86% | |
Acute myeloblastic leukaemia | 8 | 57.14% | 20 | 35.71% | |
hybrid acute leukemia | 1 | 7.14% | 1 | 1.79% | |
Myelodysplastic syndrome | 0 | 0.00% | 6 | 10.71% | |
Chronic myeloid leukaemia | 1 | 7.14% | 2 | 3.57% | |
Aggressive lymphoma | 1 | 7.14% | 2 | 3.57% | |
myelofibrosis | 0 | 0.00% | 1 | 1.79% | |
Donor type | 0.437 | ||||
Unrelated donor | 3 | 21.43% | 9 | 16.07% | |
Haploidentical-related donor | 8 | 57.14% | 31 | 55.36% | |
Matched sibling donors | 3 | 21.43% | 16 | 28.57% | |
ATG given as conditioning | 12 | 85.71% | 41 | 73.21% | 0.305 |
Conditioning intensity | 0.774 | ||||
MAC | 13 | 92.86% | 52 | 92.86% | |
RIC | 1 | 7.14% | 4 | 7.14% | |
GVHD prophylaxis | |||||
CSA based | 5 | 35.71% | 42 | 75.00% | 0.344 |
FK 506 based | 9 | 64.29% | 14 | 25.00% | 0.009 |
TB occurrence (months after HSCT) | 6.95 | 1.54–32.46 | N/A | ||
3-year overall survival after HSCT | 8 | 57.14% | 43 | 76.79% | 0.102 |
NRM at 3 years after HSCT | 5 | 30.36 ± 13.55% | 3 | 5.39 ± 3.06% | 0.002 |
aGVHD (%) | 0.013 | ||||
Grades0–1 | 5 | 35.71% | 41 | 73.21% | |
Grades2–4 | 9 | 64.29% | 15 | 26.79% | |
*cGVHD (%) group after HSCT ≥100d | 0.033 | ||||
none-mild | 4 | 40% | 32 | 80% | |
moderate-severe | 6 | 60% | 8 | 20% | |
Cytomegalovirus viremia | 11 | 78.57% | 30 | 53.57% | 0.123 |
Epstein Barr virus viremia | 13 | 92.86% | 30 | 53.57% | 0.032 |
Invasive fungal disease | 11 | 78.57% | 13 | 23.21% | 0.012 |
Follow-up duration, median months (range) | 18.27 | 3.93–88.21 | 27.14 | 3.89–87.93 | 0.219 |
Patients who died(range) | 12.05 | 3.93–39.79 | 13.93 | 3.89–51.86 | |
Patients alive at last follow-up(range) | 42.02 | 13.43–88.21 | 43.07 | 11.04–87.93 | |