Table 1 Regulated pathways between GH and IFN treated macrophages.
From: Growth hormone-mediated reprogramming of macrophage transcriptome and effector functions
Kegg Pathways | GH | IFN | Set size | ||
|---|---|---|---|---|---|
Stat Mean | P-Value | Stat Mean | P-Value | ||
Common up-regulated pathways | |||||
mmu04621 NOD-like receptor signaling pathway | 3.54 | 0.0003 | 1.92 | 0.0294 | 47 |
mmu04622 RIG-I-like receptor signaling pathway | 3.23 | 0.0009 | 2.91 | 0.0024 | 45 |
mmu04620 Toll-like receptor signaling pathway | 3.17 | 0.0010 | 2.40 | 0.0091 | 73 |
mmu04630 Jak-STAT signaling pathway | 2.69 | 0.0040 | 4.03 | 0.0000 | 75 |
mmu04380 Osteoclast differentiation | 2.23 | 0.0136 | 2.64 | 0.0045 | 92 |
mmu04623 Cytosolic DNA-sensing pathway | 2.22 | 0.0153 | 2.59 | 0.0062 | 36 |
mmu04210 Apoptosis | 2.13 | 0.0176 | 2.48 | 0.0071 | 71 |
mmu04510 Focal adhesion | 2.03 | 0.0220 | 2.43 | 0.0079 | 113 |
mmu04666 Fc gamma R-mediated phagocytosis | 1.86 | 0.0327 | 2.19 | 0.0151 | 72 |
mmu04514 Cell adhesion molecules (CAMs) | 1.77 | 0.0404 | 2.64 | 0.0051 | 52 |
IFN up-regulated pathways | |||||
mmu04145 Phagosome | — | — | 2.89 | 0.0021 | 104 |
mmu04612 Antigen processing and presentation | — | — | 2.93 | 0.0022 | 42 |
mmu04650 Natural killer cell mediated cytotoxicity | — | — | 1.98 | 0.0249 | 71 |
mmu00760 Nicotinate and nicotinamide metabolism | — | — | 2.01 | 0.0273 | 17 |
mmu04512 ECM-receptor interaction | — | — | 1.82 | 0.0373 | 28 |
mmu04912 GnRH signaling pathway | — | — | 1.70 | 0.0457 | 58 |
mmu04973 Carbohydrate digestion and absorption | — | — | 1.70 | 0.0485 | 21 |
GH up-regulated pathways | |||||
mmu04670 Leukocyte transendothelial migration | 2.65 | 0.0045 | — | — | 62 |
mmu04920 Adipocytokine signaling pathway | 2.21 | 0.0152 | — | — | 46 |
mmu04722 Neurotrophin signaling pathway | 2.12 | 0.0177 | — | — | 104 |
mmu04660 T cell receptor signaling pathway | 2.04 | 0.0217 | — | — | 73 |
mmu04062 Chemokine signaling pathway | 1.88 | 0.0310 | — | — | 114 |
mmu04662 B cell receptor signaling pathway | 1.76 | 0.0405 | — | — | 64 |
mmu04664 Fc epsilon RI signaling pathway | 1.72 | 0.0440 | — | — | 52 |
mmu04520 Adherens junction | 1.68 | 0.0486 | — | — | 49 |
Common down-regulated pathways | |||||
mmu00190 Oxidative phosphorylation | −5.80 | 0.0000 | −2.32 | 0.0108 | 98 |
mmu03030 DNA replication | −4.64 | 0.0000 | −2.07 | 0.0219 | 35 |
mmu03010 Ribosome | −5.89 | 0.0000 | −1.68 | 0.0483 | 80 |
mmu03430 Mismatch repair | −4.06 | 0.0001 | −2.14 | 0.0200 | 22 |
mmu04110 Cell cycle | −3.18 | 0.0008 | −3.31 | 0.0005 | 113 |
mmu03420 Nucleotide excision repair | −2.61 | 0.0054 | −1.78 | 0.0398 | 42 |
mmu03040 Spliceosome | −2.53 | 0.0061 | −1.72 | 0.0439 | 115 |
mmu03440 Homologous recombination | −2.42 | 0.0097 | −1.82 | 0.0384 | 27 |
mmu00982 Drug metabolism - cytochrome P450 | −1.90 | 0.0338 | −1.85 | 0.0391 | 16 |
IFN down-regulated pathways | |||||
mmu00280 Valine, leucine and isoleucine degradation | — | — | −1.98 | 0.0261 | 38 |
mmu00100 Steroid biosynthesis | — | — | −2.00 | 0.0281 | 14 |
mmu04710 Circadian rhythm - mammal | — | — | −1.93 | 0.0313 | 19 |
mmu03008 Ribosome biogenesis in eukaryotes | — | — | −1.87 | 0.0318 | 68 |
mmu04114 Oocyte meiosis | — | — | −1.82 | 0.0353 | 84 |
mmu00650 Butanoate metabolism | — | — | −1.80 | 0.0431 | 14 |
GH down-regulated pathways | |||||
mmu03410 Base excision repair | −3.49 | 0.0005 | — | — | 30 |
mmu04260 Cardiac muscle contraction | −2.69 | 0.0046 | — | — | 32 |
mmu00240 Pyrimidine metabolism | −2.30 | 0.0114 | — | — | 81 |
mmu00230 Purine metabolism | −1.90 | 0.0291 | — | — | 116 |
mmu00980 Metabolism of xenobiotics by cytochrome P450 | −1.95 | 0.0308 | — | — | 16 |