Table 1 Regulated pathways between GH and IFN treated macrophages.

From: Growth hormone-mediated reprogramming of macrophage transcriptome and effector functions

Kegg Pathways

GH

IFN

Set size

Stat Mean

P-Value

Stat Mean

P-Value

Common up-regulated pathways

mmu04621 NOD-like receptor signaling pathway

3.54

0.0003

1.92

0.0294

47

mmu04622 RIG-I-like receptor signaling pathway

3.23

0.0009

2.91

0.0024

45

mmu04620 Toll-like receptor signaling pathway

3.17

0.0010

2.40

0.0091

73

mmu04630 Jak-STAT signaling pathway

2.69

0.0040

4.03

0.0000

75

mmu04380 Osteoclast differentiation

2.23

0.0136

2.64

0.0045

92

mmu04623 Cytosolic DNA-sensing pathway

2.22

0.0153

2.59

0.0062

36

mmu04210 Apoptosis

2.13

0.0176

2.48

0.0071

71

mmu04510 Focal adhesion

2.03

0.0220

2.43

0.0079

113

mmu04666 Fc gamma R-mediated phagocytosis

1.86

0.0327

2.19

0.0151

72

mmu04514 Cell adhesion molecules (CAMs)

1.77

0.0404

2.64

0.0051

52

IFN up-regulated pathways

mmu04145 Phagosome

2.89

0.0021

104

mmu04612 Antigen processing and presentation

2.93

0.0022

42

mmu04650 Natural killer cell mediated cytotoxicity

1.98

0.0249

71

mmu00760 Nicotinate and nicotinamide metabolism

2.01

0.0273

17

mmu04512 ECM-receptor interaction

1.82

0.0373

28

mmu04912 GnRH signaling pathway

1.70

0.0457

58

mmu04973 Carbohydrate digestion and absorption

1.70

0.0485

21

GH up-regulated pathways

mmu04670 Leukocyte transendothelial migration

2.65

0.0045

62

mmu04920 Adipocytokine signaling pathway

2.21

0.0152

46

mmu04722 Neurotrophin signaling pathway

2.12

0.0177

104

mmu04660 T cell receptor signaling pathway

2.04

0.0217

73

mmu04062 Chemokine signaling pathway

1.88

0.0310

114

mmu04662 B cell receptor signaling pathway

1.76

0.0405

64

mmu04664 Fc epsilon RI signaling pathway

1.72

0.0440

52

mmu04520 Adherens junction

1.68

0.0486

49

Common down-regulated pathways

mmu00190 Oxidative phosphorylation

−5.80

0.0000

−2.32

0.0108

98

mmu03030 DNA replication

−4.64

0.0000

−2.07

0.0219

35

mmu03010 Ribosome

−5.89

0.0000

−1.68

0.0483

80

mmu03430 Mismatch repair

−4.06

0.0001

−2.14

0.0200

22

mmu04110 Cell cycle

−3.18

0.0008

−3.31

0.0005

113

mmu03420 Nucleotide excision repair

−2.61

0.0054

−1.78

0.0398

42

mmu03040 Spliceosome

−2.53

0.0061

−1.72

0.0439

115

mmu03440 Homologous recombination

−2.42

0.0097

−1.82

0.0384

27

mmu00982 Drug metabolism - cytochrome P450

−1.90

0.0338

−1.85

0.0391

16

IFN down-regulated pathways

mmu00280 Valine, leucine and isoleucine degradation

−1.98

0.0261

38

mmu00100 Steroid biosynthesis

−2.00

0.0281

14

mmu04710 Circadian rhythm - mammal

−1.93

0.0313

19

mmu03008 Ribosome biogenesis in eukaryotes

−1.87

0.0318

68

mmu04114 Oocyte meiosis

−1.82

0.0353

84

mmu00650 Butanoate metabolism

−1.80

0.0431

14

GH down-regulated pathways

mmu03410 Base excision repair

−3.49

0.0005

30

mmu04260 Cardiac muscle contraction

−2.69

0.0046

32

mmu00240 Pyrimidine metabolism

−2.30

0.0114

81

mmu00230 Purine metabolism

−1.90

0.0291

116

mmu00980 Metabolism of xenobiotics by cytochrome P450

−1.95

0.0308

16