Figure 6
From: miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44
Effect of miR-192-5P on tumour growth in vivo. A lung cancer bone metastasis model was established by injecting A549 cells (5 × 106 cells) into the marrow cavity of nude mice (12 mice per group). (A) Representative images of femur tumours in nude mice. (B) Tumour size was measured using Vernier callipers once a week until the animals were sacrificed. (C) Tumour volume was measured at the last time point. (D) Representative H&E staining (100× magnification) and immunohistochemistry images for TRIM44 (40× magnification) in tumour sections from different groups. TRIM44 protein expression in tumour tissues was examined by western blotting (E) and quantified (F). Each bar represents the mean ± SEM. *P < 0.05.
