Figure 7 | Scientific Reports

Figure 7

From: Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models

Figure 7

Detailed binding mode of PTX to AtSHMT2. PTX (orange bonds) interacts with the protein via an extensive network of hydrogen bonds (dashed, black lines; distances are given in Å), mostly mediated by water molecules (light blue circles). Hydrophobic interactions are indicated by “eyelashes”. Chain B of AtSHMT2-PTX complex is shown; EG, ethylene glycol molecule.

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