Figure 8
Comparison of hcSHMT, hmSHMT, AtSHMT2, and AtSHMT4. In Panel (A), bars above the sequences indicate residue conservation. Residues interacting with P-, B-, and E-moieties are marked with blue squares, yellow circles, and red triangles, respectively, and labeled with a corresponding letter. Panels (B,C) show pairwise structural comparisons of cytosolic AtSHMT4 (gray and teal subunits; blue MTX) with hcSHMT (coral, green), and of mitochondrial AtSHMT2 (gray, teal; orange PTX) with hmSHMT (coral, green; navy PTX). Residues and their numbering are given for plant/human isoforms. Antifolates are shown in ball-and-stick representation.
