Table 2 Methotrexate and pemetrexed Inhibition constant values obtained with human cytosolic (hcSHMT) and plant SHMT isoforms.

From: Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models

SHMT isoform

KiMTX (µM)

KiPTX (µM)

hcSHMT

a201.0 ± 19

b19.1 ± 3.1

AtSHMT4

179.3 ± 9.3

95.1 ± 9.3

AtSHMT2

270.2 ± 62.5

119.4 ± 13.2

  1. aApparent inhibition constant from Paiardini et al.45.
  2. bInhibition constant from Daidone et al.26.
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