Table 4 Literature review: Radiosurgical results of CCMs (>100 cases, follow-up duration > 4 years).
From: Gamma Knife radiosurgery for cerebral cavernous malformation
Study, year | Case no. | Margin dose (Gy) | Annual hemorrhage rate (%) | Morbidity (%, radiosurgery-related, AREs) | Mortality (%) | ||
|---|---|---|---|---|---|---|---|
Pre-GKS | Post-GKS | FU (m) | |||||
Liscak et al., 2000 | 107 | 16.0 | 2.0 | 1.6 | 48 | 4.5% | 1.9% |
Liu et al., 2005 | 125 | 12.1 | 29.2 | 10.3 (<2 yr) → 3.3 (>2 yr) | 65 | 2.4% | 0% |
Kida et al., 2015 | 298 | 14.6 | 21.4 | 7.4 (<2 yr) → 2.8 (>2 yr) | 68 | 6.7% | 2.3% |
Present study | 261 | 11.9 | 23.6 | All hemorrhages 9.02% (<2 yr) → 7.52 (>2 yr) Symptomatic hemorrhages 3.22 (<2 yr) → 3.16 (>2 yr) | 61 | 3.1% | 0.4% |
