Table 4 Results of logistic regression, effect of a shorter duration of action (<4 months) of intravitreal dexamethasone implantation in DME patients.

From: Factors associated with the duration of action of dexamethasone intravitreal implants in diabetic macular edema patients

 

Category

n(%)

Univariate

Multivariate

OR (95%CI)

p

OR (95%CI)

p

Sex

Female

31 (65.96%)

Reference

   

Male

16 (34.04)

2.40 (0.61,12.11)

0.238

  

Age (years)

≤57

32 (68.09%)

Reference

   

>57

15 (31.91%)

0.99 (0.28, 3.42)

0.989

  

HbA1c

≤7

15 (31.91%)

Reference

   

>7

32 (68.09%)

0.69 (0.16, 2.59)

0.598

  

DMR stage

NPDR

19 (40.43%)

Reference

   

PDR

28 (59.57%)

0.41 (0.10, 1.49)

0.194

  

CST (μm)

≤400

15 (31.91%)

Reference

   

>400

32 (68.09%)

2.62 (0.72, 9.82)

0.143

  

EZ disruption

(−)

20 (42.55%)

Reference

   

(+)

27 (57.45%)

1.28 (0.37, 4.45)

0.696

  

Number of HF

≤10

27 (57.45%)

Reference

 

Reference

 

>10

20 (42.55%)

20.46 (3.46, 394.23)

0.006

17.17 (2.80, 344.84)

0.010

Retinal morphology

type

DRT

24 (51.06%)

Reference

   

CME

23 (48.94%)

1.70 (0.50, 6.16)

0.403

  

SRD

(−)

36 (76.60%)

Reference

   

(+)

11 (23.40%)

0.46(0.11, 1.92)

0.277

  

IL-1β (pg/mL)

≤0.98

24 (51.06%)

Reference

   

>0.98

23 (48.94%)

0.77 (0.22, 2.65)

0.680

  

IL-8 (pg/mL)

≤18.18

24 (51.06%)

Reference

 

Reference

 

>18.18

23 (48.94%)

4.02 (1.11, 17.15)

0.043

2.82 (0.64, 13.85)

0.177

IL-10 (pg/mL)

<1.60

36 (76.60%)

Reference

   

≥1.60

11 (23.40%)

0.77 (0.19, 3.44)

0.718

  

IL-17 (pg/mL)

≤1.80

24 (51.06%)

Reference

   

>1.80

23 (48.94%)

0.52 (0.14, 1.78)

0.302

  

VEGF (pg/mL)

≤70.44

24 (51.06%)

Reference

   

>70.44

23 (48.94%)

1.70 (0.50, 6.16)

0.403

  

PlGF (pg/mL)

≤2.14

24 (51.06%)

Reference

   

>2.14

23 (48.94%)

1.70 (0.50, 6.16)

0.403

  
  1. DME, diabetic macular edema; OR, odds ratio; CI, confidence interval; HbA1c, glycated hemoglobin; EZ, ellipsoid zone; CST, central subfield thickness; HF, hyperreflective foci; CME, cystoid macular edema, DRT, diffuse retinal thickening; SRD, Serous retinal detachment; IL, interleukin; VEGF, vascular endothelial growth factor, PlGF, placental growth factor.