Figure 2
From: WDR76 mediates obesity and hepatic steatosis via HRas destabilization
Wdr76 knockout mice are resistant to high-fat diet (HFD)-induced obesity. (a–c) Wdr76+/+ and Wdr76−/− mice were fed a HFD (60% calories from fat) for 9 weeks (n = 10 per group). Body weight (a), body weight gain (b), and food intake (c) were analyzed. (d,e) Photographed images and weights of various organs from Wdr76+/+ and Wdr76−/− mice fed a HFD. (f–h) Serum levels of total cholesterol (f), triglyceride (g), and free fatty acids (h) in HFD-fed Wdr76+/+ and Wdr76−/− mice were measured (n = 5 per group). (i,j) GTT, ITT and area under curve (AUC) of Wdr76+/+ and Wdr76−/− mice (n = 5 per group). Data are presented as the mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.005, Student’s t-test.
