Figure 6
From: Acute pancreatitis promotes the generation of two different exosome populations
(A) Effect of exosomes (2 µg/ml) in macrophage activation. Even the exosomes from plasma control (exo PLC) results in a small activation of macrophages. However, exosomes from plasma AP (exo PLAP) induces higher induction of IL1β, CCL2 and CXCL1. PAAF exosomes also increases the expression of these mediators but not achieves statistical significance compared to control plasma. Control cells are treated with the equivalent volume of PBS. (B) In hepatocytes the only effect observed was an increase in the expression of 11βHSD2 under the treatment with PAAF exosomes. *p < 0.05 vs control; +p < 0.05 vs Exo PLC; #p < 0.05 vs Exo PLAP.
