Table 2 IC50 values of 4AP analogs at 0 mV: Hill parameters.
From: Structure-activity relationship studies of four novel 4-aminopyridine K+ channel blockers
Drug | pH 6.8 | pH 7.4 | pH 9.1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
IC50 (μM) | 95% C.I. (μM) | n | IC50 (μM) | 95% C.I. (μM) | n | IC50 (μM) | 95% C.I. (μM) | n | |
4AP | 210 | 176–244 | 4 | 199 | 190–207 | 6 | 38 | 33–44 | 4 |
3F4AP | 82 | 76–88 | 5 | 160 | 140–179 | 5 | 185 | 144–226 | 4 |
3Me4AP | 66 | 56–76 | 6 | 39 | 36–42 | 4 | 15 | 13–17 | 5 |
3MeO4AP | 357 | 325–390 | 4 | 355 | 327–382 | 4 | 492 | 446–538 | 5 |
3CF34AP | 249 | 150–348 | 5 | 690 | 633–747 | 6 | 2188 | 1317–3057 | 4 |
2CF34AP | 10,448 | 7,909–12,985 | 4 | 11,903 | 5,111–18,695 | 4 | 18,215 | 2776–33,653 | 2 |
