Table 3 IC50 and δ values of 4AP analogs at 0 mV: Woodhull parameters.

From: Structure-activity relationship studies of four novel 4-aminopyridine K+ channel blockers

Drug

*IC50 (μM)

δ

n

4AP

155 ± 12

0.41 ± 0.08

6

3F4AP

122 ± 4

0.46 ± 0.10

5

3Me4AP

21 ± 1

0.43 ± 0.10

4

3MeO4AP

329 ± 17

0.56 ± 0.02

4

3CF34AP

516 ± 51

0.46 ± 0.10

6

  1. *Mean values are given ± SD.
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