Figure 1 | Scientific Reports

Figure 1

From: Mycobacterium tuberculosis clinical isolates of the Beijing and East-African Indian lineage induce fundamentally different host responses in mice compared to H37Rv

Figure 1

Mycobacterial loads in lungs and spleen. (A) Mycobacterial loads in the lungs after intratracheal infection with Beijing-1585 (black bars), EAI-1627 (open bars) or H37Rv (grey bars). After 14 days Beijing-1585- and EAI-1627-infected mice rapidly become moribund, therefore no later analyses for these strains are possible. (B) Mycobacterial loads in the spleen. Three mice were used for each group at 1 dpi and 6 mice for each group at the remaining time points. The numbers above the bars indicate the number of mice out of n = 6 in total with positive cultures. Inoculum sizes were 1.0.105 CFU for Beijing, 1.3.105 CFU for EAI and 1.8.105 CFU for H37Rv. *p < 0.05 **p < 0.01 ***p < 0.001 after Bonferroni correction.

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