Figure 3 | Scientific Reports

Figure 3

From: Mycobacterium tuberculosis clinical isolates of the Beijing and East-African Indian lineage induce fundamentally different host responses in mice compared to H37Rv

Figure 3

Cytokine protein levels in the lungs of mice infected with different Mtb strains. Protein levels were determined in lung tissue homogenates of mice infected with Beijing-1585 (black bars), EAI-1627 (open bars) or H37Rv (grey bars). (A) IL-4 levels are 4–5 fold higher for Beijing-1585 and EAI-1627 at 14 dpi compared to H37Rv at 14 dpi or 28 dpi. (B) IFN-γ levels are elevated for Beijing-1585 and EAI-1627 at 14 dpi, but are 2-fold lower compared to H37Rv at 28 dpi. (C) Beijing-1585 and EAI-1627 induced circa 7-fold lower levels of IL-17a at 14 dpi compared to H37Rv at 28 dpi. (D) TNF-α levels are circa 2-fold higher for Beijing-1585 and EAI-1627 at 14 dpi compared to H37Rv at 28 dpi. N = 5 mice per group per time point for Beijing-1585 and H37Rv and n = 4 mice for EAI, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 after Bonferroni correction.

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