Figure 4 | Scientific Reports

Figure 4

From: Assessment of the hepatoprotective effect of developed lipid-polymer hybrid nanoparticles (LPHNPs) encapsulating naturally extracted β-Sitosterol against CCl4 induced hepatotoxicity in rats

Figure 4

Liver of rat (a) from normal group showing the normal histological structure of hepatic lobule. Note normal central vein (CV) and normal hepatocytes (H). (b) Treated with CCl4 showing massive centrilobular hepatocellular necrosis associated with haemorrhage and mononuclear inflammatory cells infiltration (arrow), insert image showing ballooning degeneration of hepatocytes with pyknosis of their nuclei (black arrow) and apoptosis of hepatocytes (red arrow). (c) Co-treated with CCl4 + BSS suspension showing ballooning degeneration of hepatocytes with pyknosis of their nuclei (black arrow), apoptosis of hepatocytes (red arrow) and mononuclear inflammatory cells infiltration. (d) Co-treated with CCl4 + plain LPHNPs formula, showing ballooning degeneration of hepatocytes (black arrow) and apoptosis (red arrow). (e) Co-treated with CCl4 + BSS-LPHNPs (200 mg/kg), showing ballooning degeneration of some hepatocytes (black arrow) and cytoplasmic vacuolization and microvesicular steatosis of other hepatocytes (red arrow), (f) co-treated with CCl4 + BSS-LPHNPs (400 mg/kg) showing necrosis of sporadic hepatocytes (long arrow). (H&E, scale bar 50um, X200) (inserted images X 400).

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