Table 2 stability study of the selected BSS-LPHNPs formulation (F5).
Time (days) | Microscopic observation (presence of aggregations) | Encapsulation efficiency% | Particle size (nm) | PDI | Zeta potential (mV) |
|---|---|---|---|---|---|
At 25 °C/60 ± 5% RH | |||||
0 | No | 94.42 ± 3.8 | 181.5 ± 11.3 | 0.223 ± 0.06 | −37.34 ± 3.21 |
7 | No | 93.64 ± 2.54 | 208.5 ± 9.7 | 0.227 ± 0.09 | −36.42 ± 3.57 |
15 | yes | 90.72 ± 2.15 | 246.4 ± 10.2 | 0.292 ± 0.12 | −32.45 ± 4.72 |
30 | yes | 83.65 ± 3.12 | 293.3 ± 8.7 | 0.354 ± 0.15 | −27.64 ± 5.24 |
60 | yes | 75.63 ± 3.25 | 364.8 ± 13.4 | 0.414 ± 0.19 | −21.57 ± 3.95 |
90 | yes | 69.73 ± 4.32 | 446.7 ± 12.6 | 0.502 ± 0.15 | −18.63 ± 4.56 |
At 4 °C/60 ± 5% RH | |||||
0 | No | 94.42 ± 3.8 | 181.5 ± 11.3 | 0.223 ± 0.06 | −37.34 ± 3.21 |
7 | No | 94.12 ± 2.83 | 192.7 ± 7.9 | 0.226 ± 0.08 | −37.64 ± 4.21 |
15 | No | 93.84 ± 2.81 | 206.3 ± 10.2 | 0.235 ± 0.08 | −36.34 ± 3.54 |
30 | No | 93.53 ± 3.13 | 212.5 ± 9.7 | 0.252 ± 0.11 | −33.45 ± 4.23 |
60 | No | 91.54 ± 3.42 | 230.4 ± 12.4 | 0.307 ± 0.14 | −29.62 ± 3.87 |
90 | yes | 89.56 ± 4.56 | 242.3 ± 11.7 | 0.312 ± 0.11 | −26.05 ± 4.15 |
