Figure 1
From: Differentiating external zeitgeber impact on peripheral circadian clock resetting
Locomotor activity under zeitgeber desynchrony (ZD) conditions. (a) Schematic representation of the ZD paradigm. Rectangles indicate in-phase (food access during the dark phase; solid frame) and anti-phase days (food access during the light phase; dashed frame). (b) Fractions of animals that completely adapted to the 28-hour LD cycle (period = 28 h; n = 8) and of free-running animals (period < 28 h; n = 53) under ZD conditions. (c) Distribution of dominant free-running periods (main periodogram peaks) under ZD conditions. The dotted curve shows a Lorentzian distribution fit (peak at 25.6 h). (d) Representative activity recording of one mouse over the course of 5 ZD cycles. Green lines depict different free-running rhythm components as indicated in (e). (e) χ2 periodogram analysis of running-wheel activity of the mouse shown in (d). Green numbers indicate free-run period components as depicted in (d). (f,g) Daily activity onset relative to feeding intervals throughout the experiment (f) and averaged activity onsets over one FD-cycle relative to the start of food access (g) during ZD. Three mice were excluded due to highly fragmented activity patterns. Data are shown as means ± SEM, n = 58. Dark phases are depicted by dark grey, food access by light grey shading.
