Table 1 Most relevant affected pathway by cold exposure.

From: Effects of cold exposure revealed by global transcriptomic analysis in ferret peripheral blood mononuclear cells

Classification

Sub-classification

Number of genes

Up-regulated

Down-regulated

Gene expression

 

Transcription factor

13

53

 

RNA maturation

2

10

 

DNA structure

2

9

 

Epigenetic regulation

0

6

 

Coactivator

0

5

 

Post-transcriptional regulation

0

5

 

Corepressor

0

4

 

Interfering RNA (siRNA, miRNA)

0

2

 

RNA degradation

1

0

 

Others

2

7

Cell cycle

 

Cell proliferation

8

21

 

Cell cycle regulation

9

16

 

Apoptosis

3

6

 

Cell differentiation

3

6

 

Cell determination

1

2

Immune response

 

Immune system maturation/activation

26

17

 

Antigen recognition/presentation

5

5

 

Antigen degradation

3

2

 

Cytokine signalling

2

1

 

Others

3

3

  1. Sub-classification of most relevant affected pathway by cold exposure in PBMC based on the top regulated genes (Students’ t-test, p < 0.01).