Figure 1 | Scientific Reports

Figure 1

From: Antidepressant–like effects of fish, krill oils and Vit B12 against exposure to stress environment in mice models: current status and pilot study

Figure 1

Effects of drugs on immobility time in TST. All animals (n = 90), except the control groups (n = 18) receive CUS. CUS (n = 9) and control (n = 9) animals do not receive any drugs or vehicle and the rests are orally administered with vehicle and the treatments. The treated groups (n = 72) are treated with FO (0.32 g/kg/day, n = 18), NKO (0.5 g/kg/day, n = 18), Vit B12 (1 mg/kg/day, n = 18) and IMP (5 mg/kg/day, n = 18). Results are expressed as mean ± SEM of immobility time (in seconds). Differences are analysed using two-way ANOVA followed by post hoc Dunnett’s test. For statistical significance, *p < 0.05 and **p < 0.01 when compared to the CUS group and +p < 0.05 when FO and NKO compared to Vit B12. ǂWhen compared to the control. FO: Fish oil; NKO: Neptune Krill Oil; CUS: Chronic unpredictable stress; IMP: Imipramine EPA: Eicosapentaenoic Acid; DHA: Docosahexaenoic Acid; PLs: Phospholipids; TGA: Triglycerides; ANOVA: analyses of variance; SEM: standard error of the mean. Vehicle = 7% Tween 80 in normal saline.

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