Figure 5

Effects of drugs on antioxidant enzyme activity. All animals (n = 90), except the control groups (n = 18) receive CUS. CUS (n = 9) and control (n = 9) animals do not receive any drugs or vehicle and the rests are orally administered with vehicle and the treatments. The treated groups (n = 72) are administrated with FO (0.32 g/kg/day, n = 18), NKO (0.5 g/kg/day, n = 18), Vit B12 (1 mg/kg/day, n = 18) and IMP (5 mg/kg/day, n = 18). The hippocampi of the animals are analysed for MDA (a), H2O2(b), levels. Results are expressed as mean ± Standard Error of Mean (SEM). The differences were analysed using two-way ANOVA followed by a post hoc Dunnett’s test. For statistical significance, *p < 0.05, **p < 0.01, and ***p < 0.001 when compared to the CUS group and ^ǂp < 0.05 when FO and NKO compared to Vit B12 and ⁺p < 0.05 when compared to the control. FO:Fish oil; NKO: Neptune Krill Oil; CUS: Chronic unpredictable stress; IMP: Imipramine; MDA: Malondialdehyde; ANOVA: analyses of variance; SEM: standard error of the mean. Vehicle = 7% Tween 80 in normal saline.