Table 2 Haplotype association results for recurrent dysplasia adjusted by sex, age, HIV infection, CD4 nadir and HPV oncogenic types.

From: ADAR1 function affects HPV replication and is associated to recurrent human papillomavirus-induced dysplasia in HIV coinfected individuals

Haplotype

Frequency

P-value

P-value_sim

rs6699729

rs3766925

rs3766927

rs3766924

rs9616

rs9427097

All

Non-recurrent dysplasia

Recurrent dysplasia

A

A

C

C

A

T

0.041

0.022

0.081

0.0084

0.0064

A

A

T

C

A

T

0.249

0.271

0.204

0.075

0.084

T

T

C

C

A

G

0.139

0.132

0.151

0.336

0.338

A

T

T

C

A

T

0.069

0.061

0.089

0.349

0.361

A

T

C

C

A

G

0.015

0.019

0.008

0.525

0.592

T

T

C

C

T

T

0.252

0.256

0.24

0.647

0.656

A

T

C

T

A

T

0.177

0.179

0.177

0.879

0.886

  1. Haplotype frequencies are shown for all the patients and for dysplasia groups.
  2. *P-value_sim: corrected p-value after 10,000 permutations in the score test implemented in haplo.stats R package44.
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