Table 2 Propensity score-adjusted logistic regression analysis of choice of treatment with best supportive care alone.

From: Decision-making factors for best supportive care alone and prognostic factors after best supportive care in non-small cell lung cancer patients

Variable

Univariate Analysis

Multivariate Analysis

OR

95% CI

p-value

OR

95% CI

p-value

Age (low → high)

1.08

1.05–1.11

0.0001

1.11

1.05–1.16

0.0001

Dementia (absent vs. present)

20.4

5.85–71.4

0.0001

37.0

6.54 –200.0

0.0001

Performance status (0 → 4)

3.77

2.83–5.03

0.0001

6.10

3.83–9.71

0.0001

Patient’s desire for best supportive care alone (absent vs. present)

4.02

2.22–7.30

0.0001

22.2

6.71–76.9

0.0001

Pulmonary disease (absent vs. present)

2.13

1.34–3.39

0.001

3.83

1.64–8.93

0.002

Epidermal growth factor receptor mutation (mutant vs. wild type)

2.97

2.00–4.42

0.0001

2.68

1.29–5.56

0.008

Social background (absent vs. present)

3.39

1.46–7.81

0.004

5.44

1.22–24.4

0.027

Psychiatric disorder (absent vs. present)

4.65

1.49–14.5

0.008

9.09

1.26–66.7

0.029

Renal dysfunction (absent vs. present)

2.52

1.25–5.08

0.010

3.18

0.92–11.0

0.068

Blood disease (absent vs. present)

6.67

1.27–34.5

0.025

6.37

0.69–58.8

0.103

Aspartic acid aminotransferase (low → high)

1.02

1.002–1.03

0.031

1.01

0.99–1.03

0.366

Sex (female → male)

1.57

0.94–2.64

0.086

1.36

0.51–3.64

0.534

Histologic type (adenocarcinoma vs. others)

2.94

1.81–4.79

0.0001

 

NI

 

Albumin (low → high)

0.53

0.38–0.75

0.0001

 

NI

 

Lactate dehydrogenase (×103) (low → high)

83.3

12.4–500.0

0.0001

 

NI

 

Doctor’s recommendation about best supportive care (absent vs. present)

32.3

10.3–100.0

0.0001

 

NI

 

C-reactive protein (low → high)

1.16

1.10–1.23

0.0001

 

NI

 

White blood cells (×103) (low → high)

1.11

1.05–1.17

0.0001

 

NI

 

Stage (1 → 4)

1.27

1.10–1.46

0.001

 

NI

 
  1. Social background includes the patient’s history of public assistance and psychiatric hospitalization.
  2. Abbreviations: OR, Odds ratio; C.I., confidence interval; Variables with a p-value < 0.10 on univariate analysis were entered into the multivariate logistic analysis using the.
  3. simultaneous method. NI, not included in the best multivariate logistic regression model.
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