Table 3 Crude Cox regression analysis of survival from the beginning of best supportive care.
Variable | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | p-value | HR | 95% CI | p-value | |
Anticancer therapy (none vs. used) | 1.40 | 1.26–1.55 | 0.0001 | 1.73 | 1.27–2.37 | 0.001 |
Performance status (0 → 4) | 1.70 | 1.48–1.94 | 0.0001 | 1.66 | 1.44–1.93 | 0.0001 |
Disseminated intravascular coagulation (absent vs. present) | 4.85 | 2.72–8.66 | 0.0001 | 3.74 | 2.01–6.96 | 0.0001 |
Age (low → high) | 0.96 | 0.95–0.98 | 0.0001 | 0.97 | 0.95–0.98 | 0.0001 |
White blood cell (×103) (low → high) | 1.05 | 1.03–1.07 | 0.0001 | 1.02 | 1.01–1.04 | 0.007 |
Lactate dehydrogenase (×103) (low → high) | 1.01 | 1.003–1.02 | 0.007 | 1.01 | 1.00–1.02 | 0.011 |
Dementia (absent vs. present) | 0.61 | 0.38–0.96 | 0.034 | 0.66 | 0.40–1.08 | 0.10 |
Alanine transaminase (low → high) | 1.002 | 1.001–1.004 | 0.006 | 1.001 | 0.999–1.003 | 0.33 |
Brain metastasis (absent vs. present) | 1.53 | 1.12–2.09 | 0.007 | 0.99 | 0.72–1.36 | 0.94 |
Blood urea nitrogen (low → high) | 1.01 | 0.999–1.02 | 0.092 | 0.998 | 0.99–1.01 | 0.69 |
Stage (1 → 4) | 1.30 | 1.14–1.48 | 0.0001 |  | NI |  |
Hemoglobin (low → high) | 0.84 | 0.79–0.89 | 0.0001 |  | NI |  |
Albumin (low → high) | 0.40 | 0.32–0.49 | 0.0001 |  | NI |  |
C-reactive protein (low → high) | 1.04 | 1.03–1.06 | 0.0001 |  | NI |  |
Patient’s wish about best supportive care (absent vs. present) | 0.45 | 0.32–0.62 | 0.0001 |  | NI |  |
Doctor’s decision about best supportive care (absent vs. present) | 2.13 | 1.48–3.09 | 0.0001 |  | NI |  |
Transfer to hospice or home (absent vs. present) | 0.44 | 0.37–0.53 | 0.0001 |  | NI |  |
Liver dysfunction (absent vs. present) | 1.46 | 0.96–2.21 | 0.074 |  | NI |  |