Table 4 Propensity score adjusted Cox regression analysis of survival from the beginning of best supportive care.

From: Decision-making factors for best supportive care alone and prognostic factors after best supportive care in non-small cell lung cancer patients

Variable

Univariate analysis

Multivariate Analysis

HR

95% CI

p-value

HR

95% CI

p-value

Age (low → high)

0.96

0.95–0.98

0.0001

0.97

0.95–0.98

0.0001

Performance status (0 → 4)

1.62

1.40–1.88

0.0001

1.54

1.31–1.82

0.0001

Disseminated intravascular coagulation (absent vs. present)

4.38

2.40–8.00

0.0001

3.35

1.75–6.39

0.0001

Anticancer therapy (none vs. used)

2.07

1.51–2.84

0.0001

1.62

1.17–2.24

0.001

White blood cell (×103) (low → high)

1.06

1.04–1.08

0.0001

1.03

1.01–1.05

0.002

Lactate dehydrogenase (×103) (low → high)

1.01

1.001–1.02

0.025

1.01

1.002–1.02

0.015

Dementia (absent vs. present)

0.53

0.33–0.85

0.008

0.65

0.40–1.08

0.09

Alanine aminotransferase (low → high)

1.002

1.001–1.004

0.008

1.001

0.999–1.003

0.38

M factor (0 → 1)

1.33

0.99–1.78

0.061

1.09

0.77–1.55

0.62

T factor (1 → 4)

1.16

1.06–1.27

0.001

1.02

0.93–1.12

0.67

Hemoglobin (low → high)

0.87

0.82–0.93

0.0001

 

NI

 

Albumin (low → high)

0.42

0.33–0.53

0.0001

 

NI

 

C-reactive protein (low → high)

1.03

1.02–1.05

0.0001

 

NI

 

Doctor’s decision about best supportive care (absent vs. present)

0.03

0.006–0.18

0.0001

 

NI

 

Stage (1 → 4)

1.25

1.10–1.43

0.001

 

NI

 

Number of chemotherapy courses (0 → 9)

1.08

1.01–1.16

0.018

 

NI

 

Aspartic acid aminotransferase (low → high)

1.001

1.000–1.002

0.018

 

NI

 

N factor (0 → 3)

1.13

0.995–1.28

0.060

 

NI

 
  1. Abbreviations: HR, Hazard ratio; C.I., confidence interval; Variables with a p-value < 0.10 on univariate analysis were entered into the multivariate Cox analysis.
  2. using a simultaneous method. NI, not included in the best multivariate Cox regression model.
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