Figure 5

(A) CAS, PAS and mid-gorge pocket of human AChE (hAChE) (4EY7). The abundance of aromatic amino acids is significantly high especially in CAS. (B) Human BuChE (hBuChE) also share the same 3D-structure in the catalytic region, but contains more hydrophilic and charged residues than AChE (particularly in PAS and mid-gorge site).