Table 1 IC50 of the series of products obtained in this study for inhibition of AChE and BuChE.

From: Phenoxyethyl Piperidine/Morpholine Derivatives as PAS and CAS Inhibitors of Cholinesterases: Insights for Future Drug Design

Compound

eeAChE IC50 µM

eqBuChE IC50 µM

>100

71.3 ± 10.7

>100

>100

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2.8 ± 1.2

>100

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>100

>100

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0.5 ± 0.05

>100

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15.8 ± 6.90

45.9 ± 9.3

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20.4 ± 9.3

8.1 ± 0.50

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59.2 ± 5.3

68.9 ± 2.3

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35.6 ± 3.7

2.5 ± 0.6

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71.7 ± 9.1

>100

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2.1 ± 1.2

>100

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>100

>100

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39.7 ± 11.2

61.7 ± 8.4

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45.9 ± 9.5

>100

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0.032

50